咖啡因的摄入或能有效延伸慢性肾脏病魔人病者

2019-08-11 02:03 来源:未知

近日,在举办的2017年美国肾脏病学会肾脏周上,来自葡萄牙的研究人员表示,咖啡因的摄入或会延长慢性肾脏疾病患者的寿命。在一般人群中咖啡因的摄入与机体长寿直接相关,为了观察是否这种效应也存在于肾脏疾病患者中,研究人员通过对2328名CKD患者进行了一项队列前瞻性研究来观察摄入咖啡因和参与者死亡率的关系,这些参与者在1999年至2010年间参与了国家的连续健康与营养状况调查。

咖啡因是世界上用得最多的兴奋剂——从好的方面看,咖啡因让人集中注意力、保持工作状态,也是精力焕发的能量来源。

图片 1

我们欧美人大都喝咖啡来提神。(译注:亚洲人喝茶)

图片来源:medicalxpress.com

也许是因为咖啡给人一种依赖品的感觉,我们常常担心喝咖啡是否会过量,甚至想完全戒掉咖啡。

研究者发现,咖啡因和全因死亡率之间或许存在一种剂量依赖的负相关关系,相比最低四分位数咖啡因摄入水平的人群而言,第二、第三和最高四分位数咖啡因摄入水平的个体的死亡风险分别会降低12%、22%和24%。

咖啡因确实容易过量——重度咖啡饮用者咖啡因摄入量高于推荐的每天400毫克。咖啡因摄入过量,尤其是摄入过快会导致失眠、焦躁、心跳加快。

研究者Bigotte Vieira博士表示,我们的研究阐明了慢性肾脏疾病患者中咖啡因摄入和死亡率之间的一种剂量依赖性的保护效应,这种关系并不依赖于潜在的多种因素,包括年龄、性别、种族、每年的家庭收入、教育水平、大概的肾小球滤过率、肌酐比值、高血压、吸烟状况、血脂异常、体重指数、此前的心血管事件和饮食(酒精摄入、碳水化合物、多不饱和脂肪酸和纤维)。

但是,绝大部分针对咖啡的研究都表明咖啡对健康不但无害,且有益。

最后研究者说道,本文研究结果表明,建议慢性肾脏疾病患者多摄入咖啡因或能有效降低其死亡率,这或许阐明了一种简单、临床有益的选择方式,尽管研究人员认为这种结果最好是在随机临床试验中进行证实,他们认为,观察性的研究并不能说明,咖啡因能够降低慢性肾脏疾病患者的死亡风险,但这只是暗示了诸如这种保护效应的可能性。

通常,我们不能说喝咖啡就一定健康——因果机制尚不明朗。但研究结果确实表明喝咖啡的人患某些疾病的风险较低。

Caffeine consumption may help kidney disease patients live longer

有些食物和饮料的确应该少吃少喝,但咖啡不应该在这个清单上,以下是原因。

Caffeine consumption may prolong the lives in patients with chronic kidney disease , according to a study that will be presented at ASN Kidney Week 2017 October 31-November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

肝健康:综合九个研究结果发现,喝咖啡可降低肝硬化风险。

Unspash/anniespratt

报告中说,一天喝一杯咖啡可以降低22%患肝硬化的风险,肝硬化主要由酗酒导致。一天喝两杯可降低43%,三杯降低57%,四杯降低65%。

来源:Alimentary Pharmacology and Therapeutics(营养药理与治疗学杂志)

Coffee consumption has been linked to a longer life in the general population. To see if this holds true for individuals with CKD, Miguel Bigotte Vieira, MD (Centro Hospitalar Lisboa Norte, in Portugal), and his colleagues examined the association of caffeine consumption with mortality among 2328 patients with CKD in a prospective US cohort, using the continuous National Health and Nutrition Examination Survey 1999-2010.

心脏病:通过分析两百份研究的报告发现,一天喝3-4杯咖啡的人可降低 19% 患心血管疾病的风险。

REUTERS/Jason Redmond

来源:BMJ (英国医学杂志)

The team found a dose-dependent inverse association between caffeine and all-cause mortality. Compared with those in the lowest quartile of caffeine consumption, those in the second, third, and highest quartiles had 12%, 22%, and 24% lower risks of dying.

二型糖尿病:一项大型的研究报告发现,每天多喝的一杯咖啡可降低7%发展成二型糖尿病的风险。

Shutterstock/Monkey Business Images

来源:JAMA Internal Medicine(美国医学会杂志·内科学)

"Our study showed a dose-dependent protective effect of caffeine consumption on mortality among patients with CKD. This association was independent of potential confounders including age, gender, race, annual family income, education level, estimated GFR, albumin/creatinine ratio, hypertension, smoking status, dyslipidemia, body mass index, previous cardiovascular events and diet: consumption of alcohol, carbohydrates, polyunsaturated fatty acids, and fibers," said Dr. Bigotte Vieira......

癌症:一项研究报告发现,重度咖啡饮用者(每天至少喝三杯)患癌风险可降低18%。

Shutterstock/mimagephotography

另一份报告说,每天至少喝一杯咖啡患肝癌的风险可降低15%,患子宫内膜癌的风险可降低8%。

一些数据还表明,喝咖啡的人不太容易患口腔癌和晚期前列腺癌。

来源:European Journal of Cancer Prevention,BMJ(欧洲癌症预防杂志,英国医学杂志)

使用安捷伦 Seahorse XF 分析仪实时分析功能代谢表型以进行干细胞研究

阿尔兹海默症和老年痴呆:一个关于咖啡摄入与脑健康的综合分析研究估测,喝咖啡的人患阿尔兹海默症、老年痴呆、认知能力衰退比不喝的人低16%。

AP Photo/Hermann J. Knippertz

也有一些较小规模的研究表明喝咖啡可以更大程度上降低患阿尔兹海默症风险。

来源:Journal of Alzheimer's Disease,European Journal of Neurology (阿兹海默症期刊,欧洲神经学杂志)

2017国际精准医疗学术及产业论坛

抑郁症:通过对5万名女性的研究表明,一周至少喝一杯咖啡可降低15%患抑郁症的风险,而每天喝2-3杯则可降低20%。

Justin Sullivan/Getty Images

通过对超过10万人的研究发现,喝咖啡的人自杀的可能性比不喝的人低45%,重度咖啡饮用者(每天4杯以上)自杀的可能性比不喝的人低53%。

来源:JAMA Internal Medicine,The World Journal of Biological Psychiatry (美国医学会杂志·内科学,世界生物精神病学期刊)

2017生物样本库网络研讨会

较低的死亡率:通过跟踪50万欧洲人16年的研究发现,每天喝3杯以上咖啡的男性死亡率比不喝的男性低12%,同样条件下,女性死亡率则低7%。

Shutterstock

值得注意的是,经常喝咖啡更不容易死于循环系统和消化系统疾病。重度咖啡饮用者的肝脏更健康。

另一个针对185855名美国人的研究证实了这个结果。每天喝一杯咖啡可降低12%的死亡率,喝2-3杯则可降低18%早逝的可能性。(脱咖啡因的咖啡也有同样的效果)

原文链接

8 ways that drinking coffee is connected to better health and a longer life

Caffeine is the most commonly used psychoactive drug in the world — for good reason. It wakes us up, helps us stay on task, and provides an oft-needed energy boost.

And most of us in the Americas and Europe get our caffeine fix from coffee.

But people often worry that they should limit their coffee consumption or cut it out completely. That's probably because coffee can feel like a crutch.

It is possible to overdo it on caffeine —many heavy coffee drinkers surpass the recommended limit of 400 mg of caffeine per day, and that can cause insomnia, restlessness, or a fast heartbeat, especially if consumed too fast.

But most research on coffee consumption indicates that coffee is not bad for us, and is associated with some pretty impressive health benefits.

In most cases we can't say that coffee actually causes health benefits — the causal mechanism is unclear. But research does suggest that coffee drinkers are less likely to suffer from certain illnesses.

There are plenty of foods and drinks that most of us should consume less. But here's why coffee shouldn't be on that list.

Liver health: A review that combined the results of nine studies found that drinking more coffee is associated with lower risk for cirrhosis.

In the review, drinking one cup of coffee per day was shown to be linked with a 22% reduced risk for cirrhosis, a liver disease that is often caused by heavy alcohol consumption. Two daily cups were associated with a 43% reduced risk, three cups with 57% reduced risk, and four cups with 65% reduced risk.

Source:Alimentary Pharmacology and Therapeutics

Heart disease: A review of more than 200 studies found that people who drank three or four cups of coffee per day were 19% less likely to die from cardiovascular disease.

Source:BMJ

Type 2 diabetes: One large review of studies found that every additional cup of coffee one drinks per day was correlated with a 7% reduced risk for developing Type 2 diabetes.

Source:JAMA Internal Medicine

Cancer: One review found that heavy coffee drinkers (who had at least three cups a day) had an 18% reduced risk for cancer.

Another review found that at least one cup each day was associated with 15% reduced risk for liver cancer and an 8% reduced risk for endometrial cancer.

Some data indicates that coffee drinkers may be less likely to suffer from oral/pharyngeal cancer and advanced prostate cancer as well.

Source:European Journal of Cancer Prevention,BMJ

Alzheimer's disease and dementia: A meta-analysis of studies about coffee intake and brain health calculated that regular coffee drinkers were approximately 16% less likely to suffer from Alzheimer's, dementia, or cognitive decline.

There are smaller studies that suggest drinking coffee can lead to even bigger risk reductions for Alzheimer's.

Source:Journal of Alzheimer's Disease,European Journal of Neurology

Depression: One large study of more than 50,000 women showed that drinking at least a cup of coffee each week was associated with 15% reduced risk for depression, and drinking two to three cups per day was associated with 20% reduced risk.

Another study that looked at more than 100,000 men and women found that coffee drinkers were 45% less likely to die from suicide and heavy coffee drinkers (four or more cups a day) 53% less likely to die from suicide.

Source:JAMA Internal Medicine,The World Journal of Biological Psychiatry

Overall mortality: One large study of more than 500,000 European people found that in a 16-year-period, men who drank three or more cups per day were 12% less likely to die, and women 7% less likely to die.

In particular, people were less likely to diefrom circulatory and digestive diseases. Heavy coffee drinkers also had healthier livers.

Another study of 185,855 Americans confirmed that result. People who drank one cup per day were 12% less likely to die. Two to three cups were associated with an 18% decrease in risk for early death. (Decaf had the same benefits.)

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